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Micronuclei and Cancer.

Melody DiBonaSamuel F Bakhoum
Published in: Cancer discovery (2024)
Micronuclei in chromosomally unstable cancer cells serve as pivotal catalysts for cancer progression, instigating transformative genomic, epigenetic, and transcriptional alterations. This comprehensive review not only synthesizes our present comprehension but also outlines a framework for translating this knowledge into pioneering biomarkers and therapeutics, thereby illuminating novel paths for personalized cancer management.
Keyphrases
  • papillary thyroid
  • squamous cell
  • gene expression
  • healthcare
  • dna methylation
  • transcription factor
  • childhood cancer
  • small molecule
  • oxidative stress
  • copy number
  • young adults
  • genome wide
  • metal organic framework