Tregs in the immune response of BALB/c mice experimentally infected with species of the Sporothrix genus.
Danielly Corrêa-MoreiraPaula M De LucaOrazio RomeoRodrigo C MenezesRodrigo A PaesRosely Z OliveiraAurea Ml de MoraesReginaldo G de L NetoCintia de Moraes BorbaManoel Marques E de OliveiraPublished in: Future microbiology (2021)
Background: Sporotrichosis occurs through contact with contaminated soil and plant. However, the incidence of sporotrichosis as a zoonotic epidemic has increased, particularly in Rio de Janeiro. Aim: In this work, we decided to evaluate some T-cell phenotypes involved in the immune response. Materials & methods: We used flow cytometry to quantify TCD4+ and TCD8+ and Treg from immunocompetent and immunosuppressed mice infected with Sporothrix species with different levels of virulence and pathogenicity. Results: It was demonstrated the predominance of TCD4+ over the TCD8+ cells in both groups, inoculated with all the species, and percentages of Treg observed in infected immunocompetent mice. Conclusion: This regulatory phenotype can be associated with a protective immunity in the initial periods of infection.
Keyphrases
- immune response
- flow cytometry
- high fat diet induced
- induced apoptosis
- staphylococcus aureus
- biofilm formation
- risk factors
- transcription factor
- toll like receptor
- dendritic cells
- wild type
- antimicrobial resistance
- adipose tissue
- signaling pathway
- endoplasmic reticulum stress
- oxidative stress
- cell death
- cystic fibrosis
- candida albicans