Galcanezumab modulates Capsaicin-induced C-fiber reactivity.

Hauke BasedauThalea OppermannElisa Gundelwein SilvaKuan-Po Peng Arne May

Published in: Cephalalgia : an international journal of headache (2022)

CGRP-mAb changed blood flow response to capsaicin stimulation profoundly and this effect did not change over a 12-month application. Neither capsaicin-induced flare nor dermal blood flow can be used as a predictor for treatment efficacy. These data suggest that the mechanism of headache development in migraine is not entirely CGRP-mediated.

Keyphrases

blood flow
high glucose
diabetic rats
drug induced
oxidative stress
endothelial cells
electronic health record
monoclonal antibody