Dietary Cocoa Prevents Aortic Remodeling and Vascular Oxidative Stress in Diabetic Rats.

The results demonstrate for the first time that a cocoa-rich diet strongly prevents aortic stiffening and remodeling in diabetic animals and avoids aortic oxidative stress. It is suggested that this effect could be mediated via its effects on SIRT-1, NOXs, and Nrf2.