Fish-Derived Protein Hydrolysates Increase Insulin Sensitivity and Alter Intestinal Microbiome in High-Fat-Induced Obese Mice.
Maria G DaskalakiKonstantinos AxarlisAntiopi TsourekiSofia MichailidouChristina EfraimoglouIoanna LapiOurania KolliniatiEirini DermitzakiMaria VenihakiKaterina C KousoulakiAnagnostis ArgiriouChristos TsatsanisPublished in: Marine drugs (2023)
Obesity and type 2 diabetes are characterized by low-grade systemic inflammation and glucose intolerance, which can be partially controlled with nutritional interventions. Protein-containing nutritional supplements possess health-promoting benefits. Herein, we examined the effect of dietary supplementation with protein hydrolysates derived from fish sidestreams on obesity and diabetes, utilizing a mouse model of High-Fat Diet-induced obesity and type 2 diabetes. We examined the effect of protein hydrolysates from salmon and mackerel backbone (HSB and HMB, respectively), salmon and mackerel heads (HSH and HMH, respectively), and fish collagen. The results showed that none of the dietary supplements affected weight gain, but HSH partially suppressed glucose intolerance, while HMB and HMH suppressed leptin increase in the adipose tissue. We further analyzed the gut microbiome, which contributes to the metabolic disease implicated in the development of type 2 diabetes, and found that supplementation with selected protein hydrolysates resulted in distinct changes in gut microbiome composition. The most prominent changes occurred when the diet was supplemented with fish collagen since it increased the abundance of beneficial bacteria and restricted the presence of harmful ones. Overall, the results suggest that protein hydrolysates derived from fish sidestreams can be utilized as dietary supplements with significant health benefits in the context of type 2 diabetes and diet-induced changes in the gut microbiome.
Keyphrases
- type diabetes
- insulin resistance
- weight gain
- high fat diet induced
- weight loss
- adipose tissue
- low grade
- protein protein
- mouse model
- physical activity
- healthcare
- body mass index
- glycemic control
- mental health
- amino acid
- cardiovascular disease
- public health
- binding protein
- blood glucose
- high fat diet
- risk assessment
- high grade
- oxidative stress
- birth weight
- climate change
- blood pressure
- health promotion
- high glucose