White matter hyperintensity burden in acute stroke patients differs by ischemic stroke subtype.
Anne-Katrin GieseMarkus D SchirmerAdrian V DalcaRamesh SridharanKathleen L DonahueMarco NardinRobert IrieElissa C McIntoshSteven J T MockingHuichun XuJohn W ColeEva Giralt-SteinhauerJordi Jimenez-CondeChristina JernDawn O KleindorferRobin LemmensJohan WasseliusArne LindgrenTatjana RundekRalph L SaccoReinhold SchmidtPankaj SharmaAgnieszka SlowikVincent N ThijsBradford B WorrallDaniel WooSteven J KittnerPatrick F McArdleBraxton D MitchellJonathan RosandJames F MeschiaOna WuPolina GollandNatalia S Rostnull nullPublished in: Neurology (2020)
In this international multicenter, hospital-based cohort of patients with AIS, we demonstrate that vascular risk factor profiles and extent of WMH burden differ by CCS subtype, with the highest lesion burden detected in patients with SAO. These findings further support the small vessel hypothesis of WMH lesions detected on brain MRI of patients with ischemic stroke.