Expanding the molecular signatures of malignant ossifying fibromyxoid tumours with two novel gene fusions: PHF1::FOXR1 and PHF1::FOXR2.

Pooja Srivastava Megan L ZillaRana NaousDaniel MarkerPooria KhoshnoodiMelissa BurgessArmando HerraduraJinhua WuLea F SurreyIvy John

Published in: Histopathology (2023)

We expand the genetic spectrum of OFMTs with two novel gene fusions, PHF1::FOXR1 and PHF1::FOXR2. These cases confirm the previously reported tendencies for OFMTs with rare variant fusions to demonstrate malignant behavior, unusual morphology, and non-specific immunophenotype.

Keyphrases

genome wide
copy number
dna methylation
low grade
genome wide identification
gene expression
single molecule
transcription factor