Genetic Thyrotropin Regulation of Atrial Fibrillation Risk Is Mediated Through an Effect on Height.

Mingjian ShiAli M ManouchehriChristian M ShafferNataraja Sarma VaitinadinJacklyn N HellwegeJoe-Elie SalemLea K DavisJill H SimmonsDan M RodenM Benjamin ShoemakerJane F FergusonJonathan D Mosley

Published in: The Journal of clinical endocrinology and metabolism (2021)

The genetic association between TSH and increased AF risk is mediated, in part, by taller stature. Thus, some genetic mechanisms underlying TSH variability may contribute to AF risk through mechanisms determining height occurring early in life that differ from those driven by thyroid hormone-level elevations in later life.

Keyphrases

atrial fibrillation
body mass index
genome wide
copy number
gene expression