Hepatitis C virus NS5A and core protein induce fibrosis-related genes regulation on Huh7 cells through activation of LX2 cells.
Tania G Heredia-TorresVeronica Alvarado-MartínezAna R Rincón-SánchezSonia A Lozano-SepúlvedaKame A Galán-HuertaDaniel Arellanos-SotoAna M Rivas-EstillaPublished in: Annals of hepatology (2024)
We demonstrated that HCV NS5A and Core protein expression regulate LX2 activation. NS5A and Core-induced LX2 activation, in turn, regulates diverse fibrosis-related gene expression at different levels in Huh7, which can be further analyzed as potential antifibrotic targets during HCV infection.
Keyphrases
- hepatitis c virus
- induced apoptosis
- gene expression
- cell cycle arrest
- human immunodeficiency virus
- dengue virus
- dna methylation
- cell death
- endoplasmic reticulum stress
- signaling pathway
- risk assessment
- high glucose
- small molecule
- drug induced
- cell proliferation
- living cells
- binding protein
- quantum dots
- stress induced
- fluorescent probe
- single molecule