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Si Miao San Attenuates Inflammation and Oxidative Stress in Rats with CIA via the Modulation of the Nrf2/ARE/PTEN Pathway.

Pan ShenYao HuangXin BaWeiji LinKai QinHui WangMaotao DuYing HaungYu WangZhe ChenSheng-Hao Tu
Published in: Evidence-based complementary and alternative medicine : eCAM (2021)
This study demonstrated that SMS effectively alleviated the disease progression of CIA by decreasing the levels of proinflammatory cytokines and reducing oxidative stress damage, as indicated by IL-6, TNF-α, COX-2, and PGE2 levels; inhibiting the overproduction of MDA and MPO; and enhancing antioxidant enzymes by upregulating the Nrf2/ARE/PTEN signalling pathway.
Keyphrases
  • oxidative stress
  • diabetic rats
  • dna damage
  • ischemia reperfusion injury
  • induced apoptosis
  • cell proliferation
  • pi k akt
  • signaling pathway
  • rheumatoid arthritis
  • breast cancer cells
  • anti inflammatory