Transcriptional Dynamics of Hepatic Sinusoid-Associated Cells After Liver Injury.

Mike K Terkelsen Sofie M BendixenDaniel HansenEmma A H ScottAndreas Fønss MøllerRonni NielsenSusanne MandrupAnders SchlosserThomas Levin Andersen Grith Lykke Sorensen Aleksander Krag Kedar Nath Natrajan Sönke Detlefsen Henrik Dimke Kim Ravnskjaer

Published in: Hepatology (Baltimore, Md.) (2020)

Our study offers a single-cell resolved account of drug-induced injury of the mammalian liver and identifies key genes that may serve important roles in sinusoidal integrity and as markers of advanced fibrosis in human NASH.

Keyphrases

drug induced
liver injury
single cell
genome wide
induced apoptosis
endothelial cells
gene expression
adverse drug
cell cycle arrest
rna seq
transcription factor
induced pluripotent stem cells
endoplasmic reticulum stress
signaling pathway
cell proliferation
liver fibrosis