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Anti-inflammatory and antibacterial effects of human cathelicidin active fragment KR-12 in the mouse models of colitis: a novel potential therapy of inflammatory bowel diseases.

Natalia FabisiakAdam FabisiakAnna Chmielowiec-KorzeniowskaLeszek TymczynaWojciech KamyszRadzisław KordekMarta BauerElżbieta KamyszJakub Fichna
Published in: Pharmacological reports : PR (2020)
We demonstrated that KR-12 alleviates inflammation in four different mouse models of colitis what suggests KR-12 and cathelicidins as a whole are worth being considered as a potential therapeutic option in the treatment of IBD.
Keyphrases
  • mouse model
  • anti inflammatory
  • ulcerative colitis
  • endothelial cells
  • oxidative stress
  • induced pluripotent stem cells
  • stem cells
  • human health
  • risk assessment
  • mesenchymal stem cells