Obesity-Related Traits and the Development of Rheumatoid Arthritis: Evidence From Genetic Data.
Bowen TangHuwenbo ShiLars AlfredssonLars KlareskogLeonid PadyukovXia JiangPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Genetically predicted BMI significantly increases RA risk. Future studies are needed to understand the biologic mechanisms underlying this link.
Keyphrases
- rheumatoid arthritis
- disease activity
- genome wide
- weight gain
- insulin resistance
- metabolic syndrome
- interstitial lung disease
- weight loss
- ankylosing spondylitis
- body mass index
- type diabetes
- electronic health record
- current status
- high fat diet induced
- big data
- copy number
- skeletal muscle
- gene expression
- adipose tissue
- data analysis
- physical activity
- deep learning
- artificial intelligence