Nrf2 Deficiency Exacerbates Parkinson's Disease by Aggravating NLRP3 Inflammasome Activation in MPTP-Induced Mouse Models and LPS-Induced BV2 Cells.
Ranran LuXu ZhouLijie ZhangMengdie HaoXin-Ling YangPublished in: Journal of inflammation research (2024)
Inhibited Nrf2 activity can reduce the downstream antioxidant enzyme HO-1 and antioxidant levels, induce NLRP3 inflammasome activation and ASC protein assembly in microglia, and ultimately aggravate PD inflammatory response and dopamine neuron degeneration.
Keyphrases
- nlrp inflammasome
- lps induced
- inflammatory response
- oxidative stress
- induced apoptosis
- lipopolysaccharide induced
- diabetic rats
- toll like receptor
- mouse model
- anti inflammatory
- cell cycle arrest
- high glucose
- uric acid
- pi k akt
- protein protein
- endoplasmic reticulum stress
- spinal cord
- spinal cord injury
- cell death
- binding protein
- metabolic syndrome
- cell proliferation
- immune response
- small molecule
- neuropathic pain
- replacement therapy