The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 engages the glucagon-like peptide-1 incretin hormone axis to lower levels of blood glucose in db/db mice.
Qinghe MengOleg G ChepurnyColin A LeechNapat PruekprasertMegan E MolnarJames Jason CollierRobert N CooneyGeorge G HolzPublished in: Diabetes, obesity & metabolism (2022)
α7nAChR agonists improve oral glucose tolerance in db/db mice. This action is contingent to coordinate α7nAChR and GLP-1R stimulation. Thus α7nAChR agonists administered in combination with sitagliptin might serve as a new treatment for type 2 diabetes.