Volumetric glutamate imaging (GluCEST) using 7T MRI can lateralize nonlesional temporal lobe epilepsy: A preliminary study.
Peter N HadarLohith G KiniRavi Prakash Reddy NangaRussell T ShinoharaStephanie H ChenPreya ShahLaura E M WisseMark A ElliottHari HariharanRavinder ReddyJohn A DetreJoel M SteinSandhitsu DasKathryn A DavisPublished in: Brain and behavior (2021)
The ability of 3-D, volumetric GluCEST to localize seizure onset down to the hippocampal subfield in nonlesional TLE is an improvement upon our previous 2-D, single-slice GluCEST method. Eventually, we hope to expand volumetric GluCEST to whole-brain glutamate imaging, thus enabling noninvasive analysis of glutamate networks in epilepsy and potentially leading to improved clinical outcomes.