Impact of adaptive filtering on power and false discovery rate in RNA-seq experiments.
Sonja ZehetmayerMartin PoschAlexandra GrafPublished in: BMC bioinformatics (2022)
For a large range of simulation scenarios, the adaptive filter maximises the power while the simulated False Discovery Rate is bounded by the pre-defined significance level. Using the adaptive filter, it is not necessary to pre-specify a single individual filtering method optimised for a specific scenario.