HECTD1-mediated ubiquitination and degradation of Rubicon regulates autophagy and osteoarthritis pathogenesis.

Shiyao LiaoQiangqiang ZhengHaotian ShenYang GuangYuzi XuXiaolei ZhangHong-Wei OuyangZongyou Pan

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2022)

HECTD1 plays a crucial role in OA pathogenesis in which HECTD1 regulates chondrocyte autophagy by ubiquitinating and targeting Rubicon for proteasomal degradation.

Keyphrases

cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
knee osteoarthritis
rheumatoid arthritis
drug delivery