Immunologic Control of HIV-1: What Have We Learned and Can We Induce It?
Daniel C RoganMark ConnorsPublished in: Current HIV/AIDS reports (2021)
During chronic infection, the function most robustly associated with immunologic control of HIV-1 is CD8+ T cell cytotoxic capacity. This function has proven difficult to restore in HIV-specific CD8+ T cells of chronically infected progressors in vitro and in vivo. However, progress has been made in inducing an effective CD8+ T cell response prior to lentiviral infection in the macaque model and during acute lentiviral infection in non-human primates. Further study will likely accelerate the ability to induce an effective CD8+ T cell response as part of prophylactic or therapeutic strategies.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- men who have sex with men
- endothelial cells
- liver failure
- gene therapy
- south africa
- drug induced
- intensive care unit
- respiratory failure
- induced pluripotent stem cells
- acute respiratory distress syndrome
- anti inflammatory
- extracorporeal membrane oxygenation