Clinical utility of salivary pepsin measurement in patients with proton pump inhibitor-refractory gastroesophageal reflux disease symptoms: a prospective comparative study.
Tomoaki MatsumuraMakoto AraiTakeshi SuzukiToshitaka HoppoYosuke SekiShingo KasamatsuHideaki IshigamiKentaro IshikawaKenichiro OkimotoNaoki AkizueDaisuke MaruokaTomoo NakagawaTakeo OdakaYoshitaka OkamotoNaoya KatoPublished in: Esophagus : official journal of the Japan Esophageal Society (2020)
In patients with PPI-refractory nonerosive reflux disease, salivary pepsin measurement may help diagnose patients who have conclusive evidence of reflux, whereas it is not adequate for identifying patients with APE.