Wash-free 3D imaging and detection of glioma with a novel neuropotential targeted AIE probe.

Junyong WuAnyao BiFan ZhengShuai HuangYongjiang LiJipeng DingDaxiong XiangWenbin Zeng

Published in: Chemical communications (Cambridge, England) (2021)

We herein developed a novel tetraarylimidazole-based AIE probe TPIG-NP to selectively image and quantitatively detect glioma. Due to the distinct negatively charged glioma cells, TPIG-NP with an opposite charge could achieve wash-free imaging of glioma cells and 3D multicellular spheroids.

Keyphrases

living cells
high resolution
fluorescent probe
deep learning
single molecule
mass spectrometry
drug delivery
real time pcr