ZFP281 coordinates DNMT3 and TET1 for transcriptional and epigenetic control in pluripotent state transitions.

Xin HuangSophie BalmerCong LyuYunlong XiangVikas MalikHailin WangYu ZhangWei XieAnna-Katerina HadjantonakisHongwei ZhouJianlong Wang

Published in: bioRxiv : the preprint server for biology (2023)

in epiblast. ZFP281 and TET1 undergo bimodal chromatin occupancy in pluripotent state transitions.Chromatin-binding of ZFP281 and TET1 depends on the formation of R-loops at promoters.ZFP281 is necessary for the establishment and maintenance of primed pluripotency.

Keyphrases

gene expression
dna methylation
transcription factor
genome wide
dna damage
heat shock protein
cell fate