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ZFP281 coordinates DNMT3 and TET1 for transcriptional and epigenetic control in pluripotent state transitions.

Xin HuangSophie BalmerCong LyuYunlong XiangVikas MalikHailin WangYu ZhangWei XieAnna-Katerina HadjantonakisHongwei ZhouJianlong Wang
Published in: bioRxiv : the preprint server for biology (2023)
in epiblast. ZFP281 and TET1 undergo bimodal chromatin occupancy in pluripotent state transitions.Chromatin-binding of ZFP281 and TET1 depends on the formation of R-loops at promoters.ZFP281 is necessary for the establishment and maintenance of primed pluripotency.
Keyphrases
  • gene expression
  • dna methylation
  • transcription factor
  • genome wide
  • dna damage
  • heat shock protein
  • cell fate