Phenotypic overlap between atopic dermatitis and autism.
Kyong-Oh ShinDebra A CrumrineSungeun KimYerin LeeBogyeong KimKatrina AbuabaraChaehyeong ParkYoshikazu UchidaJoan S WakefieldJason M MeyerSekyoo JeongByeong Deog ParkKyungho ParkPeter M EliasPublished in: BMC neuroscience (2021)
Baseline involvement of both AD and ASD could reflect concurrent neuro- and epidermal toxicity, possibly because both epidermis and neural tissues originate from the embryonic neuroectoderm. These studies illuminate the shared susceptibility of the brain and epidermis to a known neurotoxin, suggesting that the atopic diathesis could be extended to include ASD.
Keyphrases
- autism spectrum disorder
- atopic dermatitis
- intellectual disability
- attention deficit hyperactivity disorder
- white matter
- gene expression
- resting state
- oxidative stress
- locally advanced
- case control
- squamous cell carcinoma
- cerebral ischemia
- radiation therapy
- multiple sclerosis
- rectal cancer
- brain injury
- subarachnoid hemorrhage