Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis.

Andrea StoccoroAdam R SmithLorena MoscaAlessandro MarocchiFrancesca GerardiChristian LunettaCristina CeredaStella GagliardiKatie LunnonLucia MiglioreFabio Coppedè

Published in: Clinical epigenetics (2020)

Present data reveal altered D-loop methylation levels in sporadic ALS and confirm previous evidence of an inverse correlation between D-loop methylation levels and the mtDNA copy number, as well as differences among the major familial ALS subtypes. Overall, present results suggest that D-loop methylation and mitochondrial replication are strictly related to each other and could represent compensatory mechanisms to counteract mitochondrial impairment in sporadic and SOD1-related ALS forms.

Keyphrases

amyotrophic lateral sclerosis
genome wide
copy number
dna methylation
mitochondrial dna
oxidative stress
transcription factor
gene expression
electronic health record
single cell
early onset
data analysis