Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes.
Chiara AngiolilliPawel A KabalaAleksander M GrabiecIris M Van BaarsenBradley S FergusonSamuel GarcíaBeatriz Malvar FernandezTimothy A McKinseyPaul P TakGianluca FossatiPaolo MascagniDominique L BaetenKris A ReedquistPublished in: Annals of the rheumatic diseases (2016)
Inhibition of HDAC3 in RA FLS largely recapitulates the effects of pan-HDACi in suppressing inflammatory gene expression, including type I IFN production in RA FLS. Our results identify HDAC3 as a potential therapeutic target in the treatment of RA and type I IFN-driven autoimmune diseases.