Metformin targets a YAP1-TEAD4 complex via AMPKα to regulate CCNE1/2 in bladder cancer cells.

Yanju WuQianqian ZhengYan LiGuang WangShuting GaoXiaodong ZhangXu YanXinwen ZhangJisheng XieYuanyuan WangXun SunXin MengBo YinBiao Wang

Published in: Journal of experimental & clinical cancer research : CR (2019)

The results of our study reveal a new potential regulatory pathway in which metformin inhibits cell proliferation via AMPKα/Yap1/TEAD4/CCNE1/2 axis in BLCA cells, providing new insights into novel molecular therapeutic targets for BLCA.

Keyphrases

cell proliferation
induced apoptosis
skeletal muscle
cell cycle arrest
spinal cord injury
genome wide
protein kinase
cell cycle
single cell
signaling pathway
human health
risk assessment