SARS-CoV-2 Infection Induces Ferroptosis of Sinoatrial Node Pacemaker Cells.

Yuling HanJiajun ZhuLiuliu YangBenjamin E Nilsson-PayantRomulo HurtadoLauretta A LackoXiaolu SunAravind R GadeChristina A HigginsWhitney J SissoXue DongMaple WangZhengming ChenDavid D Ho Geoffrey S Pitt Robert E Schwartz Benjamin R tenOever Todd Evans Shuibing Chen

Published in: Circulation research (2022)

Using a hamster model, we showed that primary pacemaker cells in the heart can be infected by SARS-CoV-2. Infection of hESC-derived functional SAN-like pacemaker cells demonstrates ferroptosis as a potential mechanism for causing cardiac arrhythmias in patients with COVID-19. Finally, we identified candidate drugs that can protect the SAN cells from SARS-CoV-2 infection.

Keyphrases

induced apoptosis
cell cycle arrest
cell death
endoplasmic reticulum stress
heart failure
signaling pathway
oxidative stress
vena cava