Prognostic Implications of PD-L1 Expression in Breast Cancer: Systematic Review and Meta-analysis of Immunohistochemistry and Pooled Analysis of Transcriptomic Data.

Alexios MatikasIoannis ZerdesJohn Lövrot François RichardChristos SotiriouJonas BerghAntonios ValachisTheodoros Foukakis

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

The largest to our knowledge meta-analysis on the subject informs on PD-L1 protein positivity rates and its prognostic value in breast cancer. Standardization is needed prior to routine implementation. PD-L1 gene expression is a promising prognostic factor, especially in basal-like breast cancer. Discrepant prognostic information might be related to PD-L1 gene expression in the stroma.

Keyphrases

gene expression
prognostic factors
systematic review
dna methylation
healthcare
primary care
clinical practice
big data
electronic health record
machine learning
quality improvement
young adults
amino acid
deep learning
childhood cancer
drug induced