Increased Ca2+ signaling in NRXN1α +/- neurons derived from ASD induced pluripotent stem cells.
Sahar AvazzadehKatya McDonaghJamie ReillyYanqin WangStephanie D BoomkampVeronica McInerneyJanusz KrawczykJacqueline FitzgeraldNiamh FeerickMatthew O'SullivanAmirhossein JalaliEva B FormanSally A LynchSean EnnisNele CosemansHilde PeetersPeter DockeryTimothy O'BrienLeo R QuinlanLouise GallagherSanbing ShenPublished in: Molecular autism (2019)
This is the first report to show that human NRXN1α +/- neurons derived from ASD patients' iPSCs present novel phenotypes of upregulated VGCCs and increased Ca2+ transients, which may facilitate the development of drug screening assays for the treatment of ASD.
Keyphrases
- induced pluripotent stem cells
- autism spectrum disorder
- attention deficit hyperactivity disorder
- end stage renal disease
- intellectual disability
- spinal cord
- newly diagnosed
- endothelial cells
- chronic kidney disease
- prognostic factors
- high throughput
- emergency department
- combination therapy
- spinal cord injury
- electronic health record