Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence.
Maurizio ForteFranca BianchiMaria CotugnoSimona MarchittiElena De FalcoSalvatore RaffaRosita StanzioneFlavio Di NonnoIsotta ChimentiSilvia PalmerioFrancesca PaganoVincenzo PetrozzaAndrea MicaloniMichele MadonnaMichela RelucentiMaria Rosaria TorrisiGiacomo FratiMassimo VolpeSperanza RubattuSebastiano SciarrettaPublished in: Autophagy (2019)
10 VSMCs: aortic vascular smooth muscle cells; COX4I1/COX IV: cytochrome c oxidase subunit 4I1; ECs: endothelial cells; EPCs: endothelial progenitor cells; JD: Japanese-style diet; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; NAD: nicotinamide adenine dinucleotide; NDUFC2: NADH:ubiquinone oxidoreductase subunit C2; NMN: nicotinamide mononucleotide; RD: regular diet; SHRSP: stroke-prone spontaneously hypertensive rat; SHRSR: stroke-resistant spontaneously hypertensive rat.
Keyphrases
- vascular smooth muscle cells
- blood pressure
- atrial fibrillation
- endothelial cells
- oxidative stress
- weight loss
- angiotensin ii
- simultaneous determination
- cell death
- risk assessment
- mass spectrometry
- cerebral ischemia
- endoplasmic reticulum stress
- aortic valve
- heart failure
- signaling pathway
- high resolution
- brain injury
- liquid chromatography
- subarachnoid hemorrhage
- pulmonary arterial hypertension
- vascular endothelial growth factor
- high density