Molecular evolutionary process of advanced gastric cancer during sequential chemotherapy detected by circulating tumor DNA.
Wenqi XiChenfei ZhouFei XuDebin SunShengzhou WangYawei ChenJun JiTao MaJunwei WuChengfang ShangguanZhenggang ZhuJun ZhangPublished in: Journal of translational medicine (2022)
Baseline and dynamic changes of genomic features of ctDNA could be biomarkers for predicting response of platinum-based first-line chemotherapy in AGC patients. After treatment with standard chemotherapy regimens, convergent oncologic pathway enrichment was identified, which is yet characterized by inter-patient heterogenous gene-level CNVs.
Keyphrases
- circulating tumor
- locally advanced
- cell free
- circulating tumor cells
- end stage renal disease
- newly diagnosed
- rectal cancer
- copy number
- genome wide
- ejection fraction
- chronic kidney disease
- neoadjuvant chemotherapy
- prognostic factors
- single molecule
- squamous cell carcinoma
- dna methylation
- case report
- peritoneal dialysis
- chemotherapy induced
- radiation therapy
- radical prostatectomy
- prostate cancer
- robot assisted
- genome wide identification