Enantioselective reaction of N -cyano imines: decarboxylative Mannich-type reaction with malonic acid half thioesters.

Yusuke OyamadaKazuto InabaTakahiro Sasamori Shuichi Nakamura

Published in: Chemical communications (Cambridge, England) (2022)

The enantioselective reaction of imines bearing a cyano group as an activating group with malonic acid half thioesters gave chiral cyanamide derivatives with high enantioselectivity. The density functional theory (DFT) calculation clarified the stereochemical outcome and importance of the N -cyano group for imines.

Keyphrases

density functional theory
molecular dynamics
signaling pathway
electron transfer
mass spectrometry