Nickel-catalyzed enantioselective umpolung hydrogenation for stereoselective synthesis of β-amido esters.
Jianrong Steve ZhouSiyu GuoXiaohu ZhaoYonggui Robin ChiPublished in: Chemical communications (Cambridge, England) (2021)
Nickel complexes ligated by strongly donating diphosphines catalyze enantioselective hydrogenation for the preparation of acyclic and cyclic β-amido esters. A combination of acetic acid and indium powder provides protons and electrons to form nickel hydrido complexes under umpolung hydrogenation conditions.