Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection.
Tad EichlerKristin BenderMatthew J MurthaLaura SchwartzJackie MethenyLindsey SoldenRobert M JaggersMichael T BaileySudipti GuptaClaudia MosqueraChristina ChingKrista La PerleBirong LiBrian BecknellJohn David SpencerPublished in: Journal of the American Society of Nephrology : JASN (2019)
These findings provide evidence that RNase 7 has a role in kidney and bladder host defense against UPEC and establish a foundation for investigating RNase 7 as a UTI prognostic marker or nonantibiotic-based therapy.