Acute Dapagliflozin Administration Ameliorates Cardiac Surgery-Associated Acute Kidney Injury in a Rabbit Model.

Kensaku MatsudaHiroshi MitsuoTakuya NishijimaHikaru UchiyamaTobuhiro NitaShogo MatsunagaNoriko FujimotoTomoki UshijimaYusuke AndoMeikun Kan-OGen ShinoharaSatoshi KimuraHiromichi SonodaAkira Shiose

Published in: Circulation journal : official journal of the Japanese Circulation Society (2024)

Acute intravenous administration of dapagliflozin protects against CPB-induced AKI. Dapagliflozin may have direct renoprotective effects in renal tubular cells.

Keyphrases

liver failure
cardiac surgery
drug induced
acute kidney injury
respiratory failure
high glucose
induced apoptosis
aortic dissection
cell cycle arrest
hepatitis b virus
high dose
diabetic rats
oxidative stress
low dose
intensive care unit
cell death
endoplasmic reticulum stress