Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition.
Isabel JiménezJúlia CarabiaSabela BobilloCarles PalacioPau AbrisquetaCarlota PagèsJuan C NietoJosep CastellvíFrancisco Martínez-RicarteLourdes EscodaCristóbal PerlaDennis H Céspedes TorrezJoan BoixNoelia PurroyLluís PuigdefàbregasJoan SeoaneFrancesc BoschMarta CrespoPublished in: Journal of neuro-oncology (2020)
These data highlight the pathogenic role of the innate immune microenvironment in PCNSL and provide pre-clinical evidence for the development of selinexor and ibrutinib as a new promising therapeutic option with cytotoxic and immunomodulatory potential.