Exploring the impact of diabetes on aging: insights from TERT and COL1A1 methylation.

Jessica Nathania Liamri Farizky Martriano Humardani Giovani Chandra Lisa Thalia Mulyanata Tjie Kok Fenny Irawati Hikmawan Wahyu Sulistomo Christoph Reichetzeder Sulistyo Emantoko Dwi Putra

Published in: Turkish journal of biology = Turk biyoloji dergisi (2024)

The observed alterations in the methylation levels of TERT and COL1A1 propound the hypothesis that diabetes potentially expedites the aging process, concomitantly impinging on the production of TERT and COL1A, ostensibly through the mechanism of promoter gene hypermethylation.

Keyphrases

dna methylation
genome wide
type diabetes
cardiovascular disease
glycemic control
gene expression
copy number
transcription factor
genome wide analysis