Biological tumor markers associated with local control after primary radiotherapy in laryngeal cancer: A systematic review.
Maartje G NoordhuisEmiel A KopBert Van der VegtJohannes A LangendijkBernard F A M van der LaanEd SchuuringGeertruida H de BockPublished in: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery (2020)
Cell proliferation could be of potential interest for predicting local control after primary radiotherapy in laryngeal cancer patients, whereas EGFR and p53 are not predictive in contrast to some previous analyses. Large diversity in research methods is found between studies, which results in contradictory outcomes. Future studies need to be more standardised and well described according to the REMARK criteria in order to have better insight into which biomarkers can be used as predictors of local control after primary radiotherapy.
Keyphrases
- early stage
- cell proliferation
- locally advanced
- radiation therapy
- radiation induced
- small cell lung cancer
- papillary thyroid
- magnetic resonance imaging
- type diabetes
- case control
- risk assessment
- tyrosine kinase
- current status
- skeletal muscle
- adipose tissue
- young adults
- human health
- weight loss
- squamous cell
- glycemic control