Intratumour heterogeneity, from hypothesis to the clinic.
Naing Lin ShanAdriana KahnLajos PusztaiPublished in: British journal of cancer (2022)
Recent technological advances uncovered intricate biological processes underlying intratumor heterogeneity with clinical implications. These insights led to novel biomarkers for immunotherapies, justified serial tumour biopsies for therapeutic target profiling, inspired new treatment strategies, and ultimately might yield novel therapeutics that target clonal interdependence.
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