Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity.

Elisa M CrombieSeonyoung KimStuart AdamsonHan DongTzu-Chiao LuYiju WuYajun WuYotam LevyNolan StimpleWing Moon R LamHwee Weng D HeyDominic J WithersAo-Lin HsuBoon Huat BayJulien OchalaShih-Yin Tsai

Published in: Journal of cachexia, sarcopenia and muscle (2022)

We identify 4EBP1 as a communication hub coordinating protein synthesis and degradation to protect proteostasis, revealing therapeutic potential for activating lysosomal degradation to mitigate sarcopenia.

Keyphrases

binding protein
skeletal muscle
signaling pathway
high glucose
mouse model
drug induced
network analysis
stress induced