MEK inhibition drives anti-viral defence in RV but not RSV challenged human airway epithelial cells through AKT/p70S6K/4E-BP1 signalling.
Engin BaturcamStefan VollmerHolger SchlüterRose A MaciewiczNisha KurianOuti VaaralaStephan LudwigDanen Mootoosamy CunoosamyPublished in: Cell communication and signaling : CCS (2019)
Our findings unveil MEK as a key molecular mechanism by which rhinovirus dampens the epithelial cell's antiviral response. Our study provides a better understanding of the role of signalling pathways in shaping the antiviral response and suggests the use of MEK inhibitors in anti-viral therapy against RV.