Aortic stiffness-Is kynurenic acid a novel marker? Cross-sectional study in patients with persistent atrial fibrillation.
Tomasz ZapolskiAnna KamińskaTomasz KockiAndrzej WysokińskiEwa M UrbanskaPublished in: PloS one (2020)
In patients with AF, aortic stiffness correlated positively with KYNA, biochemical risk factors of atherosclerosis and with the indices of diastolic dysfunction of LV and LA. Revealed relationship between ASI and KYNA is an original observation, suggesting a potential role of disturbed kynurenine metabolism in the pathogenesis of arterial stiffening. KYNA, synthesis of which is influenced by homocysteine, emerges as a novel, non-classical factor associated with ASI in patients with AF.
Keyphrases
- atrial fibrillation
- left ventricular
- risk factors
- aortic valve
- left atrial
- oral anticoagulants
- catheter ablation
- pulmonary artery
- left atrial appendage
- heart failure
- direct oral anticoagulants
- aortic dissection
- cardiovascular disease
- blood pressure
- oxidative stress
- percutaneous coronary intervention
- single cell
- ejection fraction
- human health
- pulmonary hypertension
- mitral valve
- type diabetes
- venous thromboembolism