Login / Signup

Palladium-catalyzed allylation of 2- and 4-alkylpyridines via N-allyl alkylidene dihydropyridine intermediates.

Grant N ShiversF Christopher Pigge
Published in: Tetrahedron letters (2023)
A method to introduce allyl or cinnamyl groups to the picolyl positions of 2- or 4-alkylpyridines is described. Substituted N-allyl pyridinium salts are first treated with base (KO t Bu) followed by catalytic [(η 3 -allyl)PdCl] 2 and PPh 3 to result in formal Pd-catalyzed transfer of N-allyl groups to the pyridine periphery. The reaction is believed to proceed through initial formation of nucleophilic alkylidene dihydropyridine intermediates that react with (π-allyl)Pd(II) electrophiles, thereby regenerating N-allyl pyridinium cations. Catalytic turnover and liberation of pyridine products is then achieved by oxidative addition of Pd(0) to these activated allyl groups.
Keyphrases
  • bone mineral density
  • body composition
  • newly diagnosed
  • postmenopausal women
  • molecular dynamics simulations