Peptide Nanotube-Templated Biomineralization of Cu2- x S Nanoparticles for Combination Treatment of Metastatic Tumor.
Yi LaiZhiai XuXianli HuLi LeiLingling LiLiang DongHaijun YuWen ZhangPublished in: Small (Weinheim an der Bergstrasse, Germany) (2019)
1D peptide nanostructures (i.e., peptide nanotubes, PNTs) exhibit tunable chemo-physical properties and functions such as improved tissue adhesion, increased cellular uptake, and elongated blood circulation. In this study, the application of PNTs as a desirable 1D template for biomineralization of Cu2- x S nanoparticles (Cu2- x S NPs, x = 1-2) is reported. Monodisperse Cu2- x S NPs are uniformly coated on the peptide nanotubes owing to the specific high binding affinity of Cu ions to the imidazole groups exposed on the surface of nanotubes. The Cu2- x S NP-coated PNTs are further covalently grafted with an oxaliplatin prodrug (Pt-CuS-PNTs) to construct a versatile nanoplatform for combination cancer therapy. Upon 808 nm laser illumination, the nanoplatform induces significant hyperthermia effect and elicits reactive oxygen species generation through electron transfer and Fenton-like reaction. It is demonstrated that the versatile nanoplatform dramatically inhibits tumor growth and lung metastasis of melanoma in a B16-F10 melanoma tumor-bearing mouse model by combined photo- and chemotherapy. This study highlights the ability of PNTs for biomineralization of metal ions and the promising potential of such nanoplatforms for cancer treatment.
Keyphrases
- cancer therapy
- aqueous solution
- photodynamic therapy
- drug delivery
- electron transfer
- mouse model
- metal organic framework
- drug release
- reactive oxygen species
- squamous cell carcinoma
- small cell lung cancer
- mental health
- nitric oxide
- radiation therapy
- climate change
- cystic fibrosis
- combination therapy
- water soluble
- cell migration