Beyond chemotherapeutics: cisplatin as a temporary buckle to fabricate drug-loaded nanogels.

Weiqi ZhangZhe ZhangChing-Hsuan Tung

Published in: Chemical communications (Cambridge, England) (2018)

A cisplatin templated nanogel with targeting capability was synthesized, inspired by cisplatin as a chemotherapeutic drug. After crosslinking the natural polysaccharide hyaluronan, a ligand for CD44, cisplatin could be removed by simple dialysis in a salt solution while the withheld drug remains entrapped.

Keyphrases

chronic kidney disease
cancer therapy
adverse drug
end stage renal disease
electronic health record
peritoneal dialysis