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Impaired Cardiac AMPK (5'-Adenosine Monophosphate-Activated Protein Kinase) and Ca 2+ -Handling, and Action Potential Duration Heterogeneity in Ibrutinib-Induced Ventricular Arrhythmia Vulnerability.

Yanan ZhaoBeibei DuPraloy ChakrabortyNathan C DenhamStephane MassePatrick F H LaiMohammed Ali AzamFilio BilliaPaaladinesh ThavendiranathanHusam Abdel-QadirGary D LopaschukKumaraswamy Nanthakumar
Published in: Journal of the American Heart Association (2024)
VA vulnerability inflicted by ibrutinib may be mediated in part by an impairment of myocardial AMPK activity. Pharmacological activation of AMPK may be a protective strategy against ibrutinib-induced cardiotoxicity.
Keyphrases
  • protein kinase
  • left ventricular
  • high glucose
  • skeletal muscle
  • chronic lymphocytic leukemia
  • diabetic rats
  • climate change
  • heart failure
  • drug induced
  • endothelial cells
  • human health