Global hypomethylation in childhood asthma identified by genome-wide DNA-methylation sequencing preferentially affects enhancer regions.
Loreen ThürmannMatthias KlösSebastian D MackowiakMatthias BiegTobias BauerNaveed IshaqueMarey MessingschlagerCarl HerrmannStefan RöderMario BauerSascha SchäubleErik FaesslerUdo HahnDieter WeichenhanOliver MückeChristoph PlassMichael BorteErika von MutiusGabriele I StanglRoger LauenerAnne M KarvonenAmandine Divaret-ChauveauJosef RiedlerJoachim HeinrichMarie StandlAndrea von BergBeate SchaafGunda HerberthMichael KabeschRoland EilsSaskia TrumpIrina LehmannPublished in: Allergy (2023)
This is the first epigenetic study based on whole genome sequencing to identify marked dysregulation of enhancer regions as a hallmark of childhood asthma.