Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold.

Angelo CortiAngelina SacchiAnna Maria GasparriMatteo MonieriGiulia AnderluzziBarbara ColomboAlessandro GoriAnna MondinoFlavio Curnis

Published in: Journal of nanobiotechnology (2021)

IsoDGR-coated gold nanospheres can be exploited as a versatile platform for single- or multi-cytokine delivery to cells of the tumor vasculature. Extremely low doses of isoDGR-coated nanodrugs functionalized with TNF or TNF plus IL12 can enhance doxorubicin anti-tumor activity.

Keyphrases

cancer therapy
rheumatoid arthritis
drug delivery
induced apoptosis
high throughput
endoplasmic reticulum stress
oxidative stress
cell proliferation
molecularly imprinted
high resolution
cell death
single cell
tandem mass spectrometry