The circuitry of the tumor microenvironment in adult and pediatric Hodgkin lymphoma: cellular composition, cytokine profile, EBV, and exosomes.

Poonam NagpalDante B Descalzi-MontoyaNiraj Lodhi

Published in: Cancer reports (Hoboken, N.J.) (2020)

The cHL microenvironment is distinct in adult and pediatric HL. Future studies are required to understand the role of interplay between H-RS cells and EBV-associated microenvironment and their clinical outcome. They may present novel therapeutic targets for the development of antilymphoma therapy.

Keyphrases

hodgkin lymphoma
epstein barr virus
stem cells
induced apoptosis
childhood cancer
diffuse large b cell lymphoma
mesenchymal stem cells
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
signaling pathway
case control
cell therapy