Prolonged Unconsciousness is Common in COVID-19 and Associated with Hypoxemia.

Greer WaldropSeyed A SafavyniaMegan E BarraSachin AgarwalDavid A BerlinAmelia K BoehmeDaniel BrodieJacky M ChoiKevin DoyleJoseph J Fins Wolfgang GanglbergerKatherine HoffmanAaron M MittelDavid RohShibani S MukerjiCaroline Der NigoghossianSoojin ParkEdward J SchenckJohn Salazar-SchicchiQi ShenEvan SholleAngela G VelazquezMaria C WallineMichael Brandon WestoverEmery N BrownJonathan VictorBrian L EdlowNicholas D SchiffJan Claassen

Published in: Annals of neurology (2022)

Survivors of severe COVID-19 commonly recover consciousness weeks after cessation of mechanical ventilation. Long recovery periods are associated with more severe hypoxemia. This relationship is not explained by sedation or brain injury identified on clinical imaging and should inform decisions about life-sustaining therapies. ANN NEUROL 2022;91:740-755.

Keyphrases

mechanical ventilation
brain injury
coronavirus disease
sars cov
acute respiratory distress syndrome
subarachnoid hemorrhage
intensive care unit
early onset
respiratory failure
high resolution
cerebral ischemia
young adults
extracorporeal membrane oxygenation
drug induced
neural network